The importance and demand for isotopes because of its medical benefits

International Atomic Energy Agency, Page 12 Share Cite Suggested Citation: Isotopes for Medicine and the Life Sciences. The National Academies Press.

The importance and demand for isotopes because of its medical benefits

International Atomic Energy Agency, Page 12 Share Cite Suggested Citation: Isotopes for Medicine and the Life Sciences. The National Academies Press. Radioisotopes are administered to patients for diagnostic purposes by inhalation, ingestion, or intravenous or intraarterial injection.

The short-lived radionuclides typically employed emit photons that are then used to image body organs, tumors, or other pathologies, or to study normal and abnormal functions. In some cases a radioisotope is administered, biological samples such as blood, urine, or breath are later collected, and the radioactivity in those samples is used to quantify some aspect of the patient's physiological functioning.

In still other cases a radioisotope is added to a biological sample itself and is used to quantify specific constituents of that sample.

The importance and demand for isotopes because of its medical benefits

More than 36, diagnostic medical procedures that use radioisotopes are performed daily in the United States, and close to million laboratory tests that use radioisotopes are performed each year Holmes, ; Society for Nuclear Medicine, Radionuclides are also used to deliver radiation therapy to a growing number of patients each year.

In the Nuclear Regulatory Commission staff estimated that approximatelypatients received such therapy from an external cobalt source, that an additional 50, patients had a sealed container of a radioisotope inserted into tissue or a body cavity in close proximity to a cancer, and that 30, patients had received an unsealed radiopharmaceutical for a similar purpose e.

All of these imaging studies, therapeutic procedures, and laboratory tests use radioisotopes to diagnose or treat a wide variety of diseases, including those responsible for the majority of deaths in the United States, such as heart disease, cancer, and stroke, as well as such conditions as complications of AIDS.

The medical use of radioisotopes offers a less invasive alternative to traditional means of diagnosis and treatment and can result in more effective patient management, substantial benefits to the patient, and significant savings to the health care system Blaufax, ; Patton, ; Specker et al.

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For example, radionuclide studies can identify metabolic and perfusion abnormalities that may occur prior to the development of anatomic abnormalities that would be detected by computed tomographic imaging or magnetic resonance imaging.

Tumor imaging studies with radionuclides can result in the avoidance of unnecessary and expensive biopsies or surgery, whereas nuclear cardiology studies can result in the avoidance of unnecessary cardiac catheterization procedures.

In recent years as the very success of nuclear medicine and the increased use of stable and radioactive isotopes have combined with the end of the Cold War to bring DOE to an important crossroad. This unfortunate choice of terms is meant to indicate that isotope production has traditionally been a secondary mission that has been started and stopped to meet the needs of the laboratories' primary missions of basic and applied research in nuclear and particle physics, nuclear weapons, and nuclear power production.

Support for all three of these areas has declined precipitously in the past decade, even as demand for isotopes has increased. The concerns of U. DOE Prices have jumped particularly for low-demand products still in the early stages of research and development, and aggressive competition from Canada in radioisotopes and from the former Soviet Union in stable isotopes and radioisotopes threatens to cut DOE out of the market altogether.

The nuclear medicine community in particular has been highly vocal in its concern that the needs of the various users in the United States will not be adequately met in a future market controlled by one or two foreign sources. Many of the needs and uses of isotopes were discussed in a report from the National Research Council, Separated Isotopes: Those reports emphasized that the United States could not maintain its leading role in the research and development of new tools in medicine without a dedicated source or sources of isotopes for its research scientists.

The workshop brought together isotope users in fields ranging from nuclear medicine, nutrition, and pharmacology to nuclear chemistry, nuclear physics, chemistry, geoscience, and environmental science and isotope producers from both the private sector and government facilities.

Workshops discussions crystallized the widespread sense of urgency about the availability of adequate future supplies of isotopes in the United States.

Other reports indicated that the isotopes needed for key radiopharmaceuticals were sometimes unavailable for diagnostic studies and therapeutic procedures, and that scientists had been forced to abandon promising lines of research because the necessary isotopes were no longer available.

The workshop participants urged the National Research Council to carry out a full study of isotope needs and availability. Thus, the Health Sciences Policy Board of the Institute of Medicine recommended that a committee be convened to undertake an intensive examination of isotope production and availability, including the education and training of those who will be required to sustain the flow of radioactive and stable materials from their sources to laboratories and bedsides.

The committee was asked: To assess current methods and systems for producing and distributing isotopically enriched material and to consider possible alternatives for ensuring adequate supplies of isotopes for a broad range of clinical and biomedical research applications.

To examine the relative merits of current and developing technologies for isotope production and the need for new technologies over the long term. To assess the relative needs for involvement of the Department of Energy and private sector in isotope production and distribution.

As part of this assessment, the committee was also asked to conduct an in-depth review of national needs for the high-energy accelerator-produced radionuclides to be produced at an NBTF in relation to other requirements in the nuclear medicine and biomedical isotope sectors.

To evaluate the comprehensive research and educational components that have been proposed for NBTF in relation in total personnel needs in the these areas.

In its deliberations, the committee was asked to address the following specific questions:Forecast Future Demand for Medical Isotopes March Expert Panel: Forecast Future Demand for Medical Isotopes September , Arlington, Virginia Because of the high capital costs of constructing and operating these facilities there has been a great reluctance to.

Equally important, we will employ the Nordion medical isotopes team, infrastructural assets and channels to market to launch our previously announced Mo product line and a number of future. Isotopes are also important in forensics because the ratio of isotopes in a given sample of material can identify its origin.

If two samples of lead contain the same mix of isotopes, for instance, it is likely that the samples came from the same source. The production of separated isotopic samples -- whereby the purity of one isotope is greatly enhanced over its natural abundance -- can be very time consuming and expensive, and supplying the amounts needed for the growing demand in the above applications is a tremendous challenge.

Isotopes of an element all have the same chemical behavior, but the unstable isotopes undergo spontaneous decay during which they emit radiation and achieve a stable state. This property of radioisotopes is useful in food preservation, archaeological dating of .

Medical Isotopes: General Concepts *listed by the following topic areas: Isotopes Stable isotopes already play an important role in research today and will become even more important to research in the future.

He expected a difference because uranium and thorium decay into different isotopes of lead. The lead from the uranium-rich ore.

Why are isotopes important? | Socratic